Next Generation Macrocycles

“The field has done well at producing technologies to serve as hit-identification plattforms. But it would be nice to try to identify lead-quality matter: ligands that have a certain affinity for a target and that also have desirable pharmacokinetic attributes for cell permeability and oral bioavailability.”

Spiros Liras
VP CV, MD Pfizer
from: Kotz, J. Bringing macrocycles full circle.
SciBX 2013, 5, doi:10.1038/scibx.2012.1176