Publication with participation of one or more author(s) from our team.
In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B2 receptor antagonist in clinical development
Author:
Anne Lesage, François Marceau, Christoph Gibson, Brigitte Loenders, Werner Katzer, Horst-Dieter Ambrosi, Jörn Saupe, Alexander Faussner, Evangelia Pardali, Jochen Knolle
Year:
2022
Journal Title:
International Immunopharmacology
Volume:
105
Page:
108523
DOI:
10.1016/j.intimp.2022.108523
The antibiotic negamycin crosses the bacterial cytoplasmic membrane by multiple routes
In vitro pharmacological profile of a new small molecule bradykinin B2 receptor antagonist
Author:
Lesage, Anne; Gibson, Christoph; Marceau, Francois; Ambrosi, Horst-Dieter; Saupe, Joern; Katzer, Werner; Chugunov, Anton O.; Efremov, Roman G.; Tytgat, Jan; Vassilevski, Alexander A.
Year:
2020
Journal Title:
Frontiers in Pharmacology
Volume:
11
Page:
916
DOI:
10.3389/fphar.2020.00916
Plant-derived molecules a-boswellic acid acetate, praeruptorin-A, and salvianolic acid-B have age-related differential effects in young and senescent human fibroblasts in vitro.
Author:
Lewinska, Anna; Sodagam, Lakshman; Bloniarz, Dominika; Siems, Karsten; Wnuk, Maciej; Rattan, Suresh I. S.
Year:
2020
Journal Title:
Molecules
Volume:
25
Issue:
1
Page:
141
DOI:
10.3390/molecules25010141
A Biocatalytic Cascade Reaction to Access a Valuable Long-Chain ω-Hydroxy Fatty Acid
Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent
Author:
Sourbier Carole; Mannes Philip Z; Liao Pei-Jyun; Linehan W Marston; Neckers Leonard; Scroggins Bradley T; Siems Karsten; Wolf Dietmar; Beutler John A
Year:
2015
Journal Title:
Oncotarget
Volume:
6
Issue:
30
Page:
29963-74
The role of natural products in drug discovery
Author:
Haustedt, Lars Ole; Siems, Karsten.
Year:
2015
Journal Title:
Small Mol. Med. Chem.
Page:
393-429
DOI:
10.1002/9781118771723.ch14
About AnalytiCon Discovery
Publications describing projects based on AnalytiCon's expertise, technology platform or chemical space.
High-throughput screening identifies a novel natural product-inspired scaffold capable of inhibiting Clostridioides difficile in vitro
Author:
Rusha Pal, Mingji Dai, Mohamed N. Seleem
Year:
2021
Journal Title:
Scientific Reports
Volume:
11
Page:
10913
DOI:
10.1038/s41598-021-90314-3
Validation of a high-throughput method for the quantification of flavanol and procyanidin biomarkers and methylxanthines in plasma by UPLC-MS
Author:
Reedmond Y. Fong Gunter G. C. Kuhnle, Alan Crozier, Hagen Schroeter, Javier I. Ottaviani
Year:
2021
Journal Title:
Food & Function
Volume:
12
Issue:
17
Page:
7762
DOI:
10.1039/D1FO01228B
Search for Potential Inducible Nitric Oxide Synthase Inhibitors with Favorable ADMET Profiles for the Therapy of Helicobacter pylori Infections
Author:
Ricardo Pereira Rodrigues, Juliana Santa Ardisson, Rita de Cássia Ribeiro Gonçalves, Tiago Branquinho Oliveira , Vinicius Barreto da Silva , Daniel Fábio Kawano and Rodrigo Rezende Kitagawa,
Year:
2019
Journal Title:
Current Topics in Medicinal Chemistry
Volume:
19
Issue:
30
Page:
2801
DOI:
10.2174/1568026619666191112105650
NP-Scout: Machine Learning Approach for the Quantification and Visualization of the Natural Product-Likeness of Small Molecules
Author:
Ya Chen , Conrad Stork , Steffen Hirte and Johannes Kirchmair
Year:
2019
Journal Title:
Biomolecules
Volume:
9
Page:
43
DOI:
10.3390/biom9020043
In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)
Author:
Georgia Melagraki, Evangelos Ntougkos, Dimitra Papadopoulou, Vagelis Rinotas, Georgios Leonis, Eleni Douni, Antreas Afantitis and George Kollias
Year:
2018
Journal Title:
Frontiers
DOI:
10.3389/fphar.2018.00800
The WEIZMASS spectral library for high-confidence metabolite identification
Author:
Nir Shahaf, Ilana Rogachev , Uwe Heinig , Sagit Meir , Sergey Malitsky, Maor Battat , Hilary Wyner, Shuning Zheng , Ron Wehrens, Asaph Aharoni
Year:
2016
Journal Title:
Nature Communications
Volume:
7
Page:
12423
DOI:
10.1038/ncomms12423
Discover natural compounds as potential phosphodiesterase-4B inhibitors via computational approaches
Author:
Jing Li, Nan Zhou, Wen Liu, Jianzong Li, Yu Feng, Xiaoyun Wang, Chuanfang Wu & Jinku Bao
Year:
2016
Journal Title:
Journal of Molecular Modeling
Volume:
34
Issue:
5
Page:
1101
DOI:
10.1080/07391102.2015.1070749
Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells
Author:
Sarah R Hengel , Eva Malacaria , Laura Folly da Silva Constantino , Fletcher E Bain , Andrea Diaz , Brandon G Koch , Liping Yu, Meng Wu , Pietro Pichierri , M Ashley Spies, Maria Spies
Year:
2016
Journal Title:
eLife
Volume:
5
DOI:
10.7554/eLife.14740
Chemical Data Visualization and Analysis with Incremental Generative Topographic Mapping: Big Data Challenge
Author:
Heléna A. Gaspar, ́ Igor I. Baskin,Gilles Marcou, Dragos Horvath,and Alexandre Varnek
