Publications

Most of our publications are free to download from the website!

Amorfrutins are potent antidiabetic dietary natural products.

Weidner C, de Groot JC, Prasad A, Freiwald A, Quedenau C, Kliem M, Witzke A, Kodelja V, Han CT, Giegold S, Baumann M, Klebl B, Siems K, Müller-Kuhrt L, Schürmann A, Schüler R, Pfeiffer AF, Schroeder FC, Büssow K, Sauer S.

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Proc Natl Acad Sci U S A. (2012) 109(19) 7257-62

The phytochemical glaucarubinone promotes mitochondrial metabolism, reduces body fat, and extends lifespan of Caenorhabditis elegans.

Zarse, K.; Bossecker, A.; Mueller-Kuhrt, L.; Siems, K.; Hernandez, M. A.; Berendsohn, W. G.; Birringer, M.; Ristow, M. Horm. Metab. Res. (2011), 43(4), 241-243

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Horm. Metab. Res. (2011), 43(4), 241-243

Revisiting old drugs as novel agents for retinoblastoma: in vitro and in vivo antitumor activity of cardenolides.

Antczak Christophe; Kloepping Carolyn; Radu Constantin; Genski Thorsten; Muller-Kuhrt Lutz; Siems Karsten; de Stanchina Elisa; Abramson David H; Djaballah Hakim

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Investigative ophthalmology & visual science (2009), 50(7), 3065-73

Structure-Based Pharmacophore Screning for Natural-Product-Derived PPARγ Agonists

Yusuf Tanrikulu, Oliver Rau, Oliver Schwarz, Ewgenij Proschak, Karsten Siems, Lutz Müller-Kuhrt, Manfred Schubert-Zsilavecz, and Gisbert Schneider

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Journal of Chemistry and BioChemistry (2009), 10, 75-78

A Cell-based High-throughput Assay System Reveals Modulation of Oxidative and Nonoxidative Glucose Metabolism due to Commonly Used Organic Solvents

S. Zimmermann, K. Zarse, T. J. Schulz, K. Siems, L. Müller-Kuhrt, M. Birringer, M. Ristow

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Hormone and Metabolic Research (2008), 40, 29-37

Burning the Hay to Find the Needle-Data Mining Strategies in Natural Product Dereplication

D. Wolf and K. Siems

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Chimia (2007, 61, 339-345

Identification of Natural-Product-Derived Inhibitors of 5-Lipoxygenase Activity by Ligand-Based Virtual Screening

Lutz Franke, Oliver Schwarz, Lutz Müller-Kuhrt, Christina Hoernig, Lutz Fischer, Sven George, Yusuf Tanrikulu, Petra Schneider, Oliver Werz, Dieter Steinhilber, and Gisbert Schneider

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Journal of Medicinal Chemistry (2007), 50, 2640-2646

Natural Products in Parallel Chemistry – Novel 5-Lipoxygenase Inhibitors from BIOS-Based Libraries Starting from α-Santonin

Oliver Schwarz, Sven Jakupovic, Horst-Dieter Ambrosi, Lars Ole Haustedt, Christian Mang, and Lutz Müller-Kuhrt

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Journal of Combinatorial Chemistry (2007), 9, 1104-1113

Successful, but often unconventional: the continued and long-term contribution of natrual products to healthcare

Lutz Müller-Kuhrt

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Expert Opinion (2007), 2(3), 305-311
Expert Opin. Drug Discov. (2007) 2(3),305-311

Discovery of protein phosphatase inhibitors classes by biology-oriented synthesis

Andrea Nören-Müller, Ivan Reis-Corrêa, Jr., Heino Prinz, Claudia Rosenbaum, Krishna Saxena, Harald J. Schwalbe, Dietmar Vestweber, Guiseppe Cagna, Stefan Schunk, Oliver Schwarz, Hajo Schiewe and Herbert Waldmann

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PNAS (2006), 103(28), 10606-10611

Rational approaches to natural-product-based drug design

Lars Ole Haustedt, Christian Mang, Karsten Siems and Hajo Schiewe

Current Opinion in Drug Discovery & Development (2006), 9(4), 445-462
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Natural Products in Combinatorial Chemistry: An Andrographolide-Based Library

Christian Mang, Sven Jakupovic, Stefan Schunk, Horst-Dieter Ambrosi, Oliver Schwarz, and Jasmin Jakupovic

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Journal of Combinatorial Chemistry (2006), 8, 268-274