Publications

By AnalytiCon Discovery

Publication with participation of one or more author(s) from our team.

In vitro pharmacological profile of PHA-022121, a small molecule bradykinin B2 receptor antagonist in clinical development

Author:
Anne Lesage, François Marceau, Christoph Gibson, Brigitte Loenders, Werner Katzer, Horst-Dieter Ambrosi, Jörn Saupe, Alexander Faussner, Evangelia Pardali, Jochen Knolle
Year:
2022
Journal Title:
International Immunopharmacology
Volume:
105
Page:
108523
DOI:
10.1016/j.intimp.2022.108523

The antibiotic negamycin crosses the bacterial cytoplasmic membrane by multiple routes

Author:
Hoeroempoeli, Daniel; Ciglia, Catherine; Gluesenkamp, Karl-heinz; Haustedt, Lars ole; Falkenstein-paul, Hildegard; Bendas, Gerd; Berscheid, Anne; Broetz-oesterhelt, Heike
Year:
2021
Journal Title:
Antimicrobial Agents and Chemotherapy
Volume:
65
Issue:
4
DOI:
10.1128/aac.00986-20

In vitro pharmacological profile of a new small molecule bradykinin B2 receptor antagonist

Author:
Lesage, Anne; Gibson, Christoph; Marceau, Francois; Ambrosi, Horst-Dieter; Saupe, Joern; Katzer, Werner; Chugunov, Anton O.; Efremov, Roman G.; Tytgat, Jan; Vassilevski, Alexander A.
Year:
2020
Journal Title:
Frontiers in Pharmacology
Volume:
11
Page:
916
DOI:
10.3389/fphar.2020.00916

Plant-derived molecules a-boswellic acid acetate, praeruptorin-A, and salvianolic acid-B have age-related differential effects in young and senescent human fibroblasts in vitro.

Author:
Lewinska, Anna; Sodagam, Lakshman; Bloniarz, Dominika; Siems, Karsten; Wnuk, Maciej; Rattan, Suresh I. S.
Year:
2020
Journal Title:
Molecules
Volume:
25
Issue:
1
Page:
141
DOI:
10.3390/molecules25010141

A Biocatalytic Cascade Reaction to Access a Valuable Long-Chain ω-Hydroxy Fatty Acid

Author:
Becker, Aileen; Boettcher, Dominique; Katzer, Werner; Siems, Karsten; Mueller-Kuhrt, Lutz; Bornscheuer, Uwe T.
Year:
2020
Journal Title:
ChemCatChem
Volume:
12
Issue:
16
Page:
4084-4089
DOI:
10.1002/cctc.202000745

Phytochemicals rosmarinic acid, ampelopsin, and amorfrutin-A can modulate age-related phenotype of serially passaged human skin fibroblasts in vitro.

Author:
Sodagam, Lakshman; Lewinska, Anna; Kwasniewicz, Ewa; Kokhanovska, Sofiya; Wnuk, Maciej; Siems, Karsten; Rattan, Suresh I. S.
Year:
2019
Journal Title:
Front. Genet.
Volume:
10
Page:
81
DOI:
10.3389/fgene.2019.00081

Multi-​gram synthesis of enantiopure 1,​5-​disubstituted tetrazoles via ugi-​azide 3-​component reaction

Author:
Capurro, Pietro; Moni, Lisa; Galatini, Andrea; Mang, Christian; Basso, Andrea
Year:
2018
Journal Title:
Molecules
Volume:
23
Issue:
11
Page:
2758
DOI:
10.3390/molecules23112758

Exploitation of the Ugi 5-Center-4-component reaction (U-5C-4CR) for the generation of diverse libraries of polycyclic (spiro)-compounds

Author:
Moni, Lisa; De Moliner, Fabio; Garbarino, Silvia; Saupe, Joern; Mang, Christian; Basso, Andrea
Year:
2018
Journal Title:
Frontiers in Chemistry
DOI:
10.3389/fchem.2018.00369

Tonantzitlolone is a nanomolar potency activator of transient receptor potential canonical 1​/4​/5 channels

Author:
Rubaiy Hussein N; Ludlow Melanie J; Beech David J; Siems Karsten; Wolf Dietmar; Norman Katherine; Foster Richard; Beutler John A
Year:
2018
Journal Title:
British journal of pharmacology
Volume:
175
Issue:
16
Page:
3361-3368

Natural 6-hydroxy-chromanols and -chromenols

Author:
Birringer, Marc; Siems, Karsten; Maxones, Alexander; Frank, Jan; Lorkowski, Stefan.
Year:
2018
Journal Title:
RSC Adv.
Volume:
8
Issue:
9
Page:
4803-4841
DOI:
10.1039/C7RA11819H

MacroEvoLution – A New Method for the Rapid Generation of Novel Scaffold Diverse Macrocyclic Libraries

Author:
Saupe, Joern; Kunz, Oliver; Haustedt, Lars Ole; Jakupovic, Sven; Mang, Christian
Year:
2017
Journal Title:
Chemistry - A European Journal
Volume:
23
Issue:
49
Page:
11784
DOI:
10.1002/chem.201703209

Human cell-based taste perception – a bittersweet job for industry.

Author:
Riedel, K.; Sombroek, D.; Fiedler, B.; Siems, K.; Krohn, M.
Year:
2017
Journal Title:
Nat. Prod. Rep.
Volume:
34
Issue:
5
Page:
484-495
DOI:
10.1039/C6NP00123H

Ageing with elegans

Author:
Luyten Walter; Antal Peter; Braeckman Bart P; Bundy Jake; Cirulli Francesca; Fang-Yen Christopher; Fuellen Georg; Leroi Armand; Liu Qingfei; Martorell Patricia; Metspalu Andres; Perola Markus; Perola Markus; Perola Markus; Ristow Michael; Saul Nadine; Schoofs Liliane; Siems Karsten; Temmerman Liesbet; Smets Tina; Wolk Alicja; Rattan Suresh I S
Year:
2016
Journal Title:
Biogerontology
Volume:
17
Issue:
4
Page:
771-82

Amorfrutin C Induces Apoptosis and Inhibits Proliferation in Colon Cancer Cells through Targeting Mitochondria.

Author:
Weidner, Christopher; Rousseau, Morten; Micikas, Robert J.; Fischer, Cornelius; Plauth, Annabell; Wowro, Sylvia J.; Siems, Karsten; Hetterling, Gregor; Kliem, Magdalena; Schroeder, Frank C.; Sauer, Sascha.
Year:
2016
Journal Title:
J. Nat. Prod.
Volume:
79
Issue:
1
Page:
2-12
DOI:
10.1021/acs.jnatprod.5b00072

Long-lasting WNT-TCF response blocking and epigenetic modifying activities of withanolide f in human cancer cells.

Author:
Seth, Chandan; Mas, Christophe; Conod, Arwen; Mueller, Jens; Siems, Karsten; Kuciak, Monika; Borges, Isabel; Ruiz i Altaba, Ariel.
Year:
2016
Journal Title:
PLoS One
Volume:
11
Issue:
12
Page:
e0168170/1-e0168170/19
DOI:
10.1371/journal.pone.0168170

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent

Author:
Sourbier Carole; Mannes Philip Z; Liao Pei-Jyun; Linehan W Marston; Neckers Leonard; Scroggins Bradley T; Siems Karsten; Wolf Dietmar; Beutler John A
Year:
2015
Journal Title:
Oncotarget
Volume:
6
Issue:
30
Page:
29963-74

The role of natural products in drug discovery

Author:
Haustedt, Lars Ole; Siems, Karsten.
Year:
2015
Journal Title:
Small Mol. Med. Chem.
Page:
393-429
DOI:
10.1002/9781118771723.ch14

About AnalytiCon Discovery

Publications describing projects based on AnalytiCon's expertise, technology platform or chemical space.

High-throughput screening identifies a novel natural product-inspired scaffold capable of inhibiting Clostridioides difficile in vitro

Author:
Rusha Pal, Mingji Dai, Mohamed N. Seleem
Year:
2021
Journal Title:
Scientific Reports
Volume:
11
Page:
10913
DOI:
10.1038/s41598-021-90314-3

Validation of a high-throughput method for the quantification of flavanol and procyanidin biomarkers and methylxanthines in plasma by UPLC-MS

Author:
Reedmond Y. Fong Gunter G. C. Kuhnle, Alan Crozier, Hagen Schroeter, Javier I. Ottaviani
Year:
2021
Journal Title:
Food & Function
Volume:
12
Issue:
17
Page:
7762
DOI:
10.1039/D1FO01228B

Search for Potential Inducible Nitric Oxide Synthase Inhibitors with Favorable ADMET Profiles for the Therapy of Helicobacter pylori Infections

Author:
Ricardo Pereira Rodrigues, Juliana Santa Ardisson, Rita de Cássia Ribeiro Gonçalves, Tiago Branquinho Oliveira , Vinicius Barreto da Silva , Daniel Fábio Kawano and Rodrigo Rezende Kitagawa,
Year:
2019
Journal Title:
Current Topics in Medicinal Chemistry
Volume:
19
Issue:
30
Page:
2801
DOI:
10.2174/1568026619666191112105650

NP-Scout: Machine Learning Approach for the Quantification and Visualization of the Natural Product-Likeness of Small Molecules

Author:
Ya Chen , Conrad Stork , Steffen Hirte and Johannes Kirchmair
Year:
2019
Journal Title:
Biomolecules
Volume:
9
Page:
43
DOI:
10.3390/biom9020043

In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

Author:
Georgia Melagraki, Evangelos Ntougkos, Dimitra Papadopoulou, Vagelis Rinotas, Georgios Leonis, Eleni Douni, Antreas Afantitis and George Kollias
Year:
2018
Journal Title:
Frontiers
DOI:
10.3389/fphar.2018.00800

The WEIZMASS spectral library for high-confidence metabolite identification

Author:
Nir Shahaf, Ilana Rogachev , Uwe Heinig , Sagit Meir , Sergey Malitsky, Maor Battat , Hilary Wyner, Shuning Zheng , Ron Wehrens, Asaph Aharoni
Year:
2016
Journal Title:
Nature Communications
Volume:
7
Page:
12423
DOI:
10.1038/ncomms12423

Discover natural compounds as potential phosphodiesterase-4B inhibitors via computational approaches

Author:
Jing Li, Nan Zhou, Wen Liu, Jianzong Li, Yu Feng, Xiaoyun Wang, Chuanfang Wu & Jinku Bao
Year:
2016
Journal Title:
Journal of Molecular Modeling
Volume:
34
Issue:
5
Page:
1101
DOI:
10.1080/07391102.2015.1070749

Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells

Author:
Sarah R Hengel , Eva Malacaria , Laura Folly da Silva Constantino , Fletcher E Bain , Andrea Diaz , Brandon G Koch , Liping Yu, Meng Wu , Pietro Pichierri , M Ashley Spies, Maria Spies
Year:
2016
Journal Title:
eLife
Volume:
5
DOI:
10.7554/eLife.14740

Chemical Data Visualization and Analysis with Incremental Generative Topographic Mapping: Big Data Challenge

Author:
Heléna A. Gaspar, ́ Igor I. Baskin,Gilles Marcou, Dragos Horvath,and Alexandre Varnek
Year:
2015
Journal Title:
J. Chem. Inf. Model
Volume:
55
Issue:
1
Page:
84
DOI:
10.1021/ci500575y
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