Screening Libraries and Collections

Collections of purified Natural Products – continuously growing

Since 2000 AnalytiCon has isolated around 20,000 different natural products. We have done this with a high level of purity and fully elucidated chemical structures. This scope illustrates our expertise in natural product chemistry in the most striking way. AnalytiCon currently offers about 5,000 different natural products. Every year a further thousand compounds are isolated – with a degree of novelty of around 50%. The high proportion of microbial substances only accessible to AnalytiCon makes this substance library unique.

Synthetic Screening Compounds

Drug research is dependent on novel approaches, now more than ever. The number of newly approved medicines with a clear health benefit for patients is too low. This is also an expression of the inadequate availability of potential new starting points. Surprising innovations are found primarily in the under explored areas of the chemical universe. Nature delivers precisely this: starting points which often surprise through their structural novelty and a new mode of action.
AnalytiCon’s synthetic libraries exploit the advantages of a natural product – for example, from biologically relevant partial structures of natural products we develop libraries which can be further optimized by medicinal chemistry. Surprises are where you least expect them.

Fragments from Nature

In the last few years, fragment-based approaches have been established as efficient techniques that speed things up in the development of active substances. AnalytiCon’s “Fragments from Nature” approach represents a possibility to integrate natural product elements into this approach. Through our “growing by catalogue” concept, we make fragments available which, in the case of an affinity worth pursuing, permits an uncomplicated development based on already established chemistry.

Macrocycles – learning from nature

Receptors with extensive and shallow binding sites are often effectively addressed through macrocyclic compounds, which are characterized by restricted conformational flexibility. The diversity in macrocyclic scaffolds accessible is, however, limited. With the implementation of the innovative “MacroEvoLution concept”, AnalytiCon has managed to establish a unique platform which systematically and efficiently allows access to higher scaffold diversity. The modular assembly makes a fast development from hit compounds to lead compounds easier.

Edible plant material: Compounds, Fractions, Extracts

Parts of plants, which represent parts of human nutrition, are largely harmless from a toxicological point of view (in terms of normal daily consumption). A benefit greatly appreciated by many food and cosmetic companies. Therefore AnalytiCon has built up an extensive collection of edible plants as well as extracts, fractions and isolated natural products produced from these. Fractions and pure substances can be used alongside the extracts for testing purposes. Our extracts have been produced from 2,000 plant partitions being the start for the generation of tens of thousands of fractions and thousands of pure natural products.

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